Moral cretinism finds its match in a kind of political cretinism: This is an age of both moral and political cretinism. It referred to a peculiar immunity that fascists had to any moral considerations or motivations.
If fetal deficiency was severe because of complete absence athyreosis of the gland, physical features Case study on cretinism include a larger anterior fontanelpersistence of a posterior fontanel, an umbilical herniaand a large tongue macroglossia.
In the era before newborn screening, less than half of cases of severe hypothyroidism were recognized in the first month of life.
As the months proceeded, these babies would grow poorly and be delayed in their development. By several years of age, they would display the recognizable facial and body features of cretinism.
Persistence of severe, untreated hypothyroidism resulted in severe mental impairment, with an IQ below 80 in the majority. Most of these children eventually ended up in institutional care. Congenital hypothyroidism, copper engraving, Cause[ edit ] Around the world, the most common cause of congenital hypothyroidism is iodine deficiency, but in most of the developed world and areas of adequate environmental iodine, cases are due to a combination of known and unknown causes.
Most commonly there is a defect of development of the thyroid gland itself, resulting in an absent athyreosis or underdeveloped hypoplastic gland.
A hypoplastic gland may develop higher in the neck or even in the back of the tongue. A gland in the wrong place is referred to as ectopic, and an ectopic gland at the base or back of the tongue is a lingual thyroid. Some of these cases of developmentally abnormal glands result from genetic defectsand some are "sporadic," with no identifiable cause.
One Japanese study found a statistical correlation between certain organochlorine insecticides and dioxin -like chemicals in the milk of mothers who had given birth to infants with congenital hypothyroidism.
One common cause of this is the presence of maternal antibodies that temporarily impair thyroid function for several weeks. The term, like so many other 19th century medical terms, acquired pejorative connotations as it became used in lay speech.
It is now deprecated; ICD uses " congenital iodine deficiency syndrome " with additional specifiers for the various types.
Genetic[ edit ] Congenital hypothyroidism can also occur due to genetic defects of thyroxine or triiodothyronine synthesis within a structurally normal gland.
Among specific defects are thyrotropin TSH resistance, iodine trapping defect, organification defect, thyroglobulinand iodotyrosine deiodinase deficiency. In a small proportion of cases of congenital hypothyroidism, the defect is due to a deficiency of thyroid stimulating hormoneeither isolated or as part of congenital hypopituitarism.
Genetic types of nongoitrous congenital hypothyroidism include:The authors describe a case of myxedema due to dysgenesis of the thyroid gland, with remaining sublingual thyroid tissue showing a significant I uptake. No abnormal iodoproteins were identified in the serum by electrophoretic studies.
An incomplete response to desiccated thyroid and an excellent response to l-triiodothyronine were observed. Dec 08, · 1 Biocultural Case Studies Phenylketonuria, Cretinism and Geophagy Diet Coke Phenylalanine pathways Phenylalanine Tyrosine 1.
Phenylalanine hydroxylase. Cretinism is a congenital condition caused by a deficiency of thyroid hormone during prenatal development and characterized in childhood by dwarfed stature, mental retardation, dystrophy of the bones, and a low basal metabolism.
The cretinism of the BJP is an important but low bar to beat. Given the poison it represents, it may still be a relief to get rid of it.
But there is not a single issue on which any of the. Oct 14, · Severe iodine deficiency results in impaired thyroid hormone synthesis and/or thyroid enlargement (goiter). Population effects of severe iodine deficiency, termed iodine deficiency disorders (IDDs), include endemic goiter, hypothyroidism, cretinism, decreased fertility rate, increased infant mortality, and mental retardation.
cretiniCase study on Cretinism Cretinism is a congenital condition caused by a deficiency of thyroid hormone during prenatal development and characterized in childhood by dwarfed stature, mental retardation, dystrophy of the bones, and a low basal metabolism.