BAT shares were sold off during the month Total value of equities held: RM, NAV price per unit:
Co-administration of quinidine or dofetilide with Itraconazole may increase plasma concentrations of quinidine or dofetilide, which could result in serious cardiovascular events.
Therefore, concomitant administration of Itraconazole and quinidine or dofetilide is contraindicated. Pharmaniaga vs hovid Class IA antiarrhythmic, disopyramide has the potential to increase the QT interval at high plasma concentrations. Caution is advised when Itraconazole and disopyramide are administered concomitantly.
Concomitant administration of digoxin and Itraconazole has led to increased plasma concentrations of digoxin via inhibition of P-glycoprotein. Reduced plasma concentrations of Itraconazole were reported when Itraconazole was administered concomitantly with phenytoin.
Although interactions with carbamazepine and phenobarbital have not been studied, concomitant administration of Itraconazole and these drugs would be expected to result in decreased plasma concentrations of Itraconazole. In addition, in vivo studies have demonstrated an increase in plasma carbamazepine concentrations in subjects concomitantly receiving ketoconazole.
Although there are no data regarding the effect of Itraconazole on carbamazepine metabolism, because of the similarities between ketoconazole and Itraconazole, concomitant administration of Itraconazole and carbamazepine may inhibit the metabolism of carbamazepine.
Human pharmacokinetic studies have shown that efavirenz, when concomitantly administered with Itraconazole, greatly decreased serum concentrations of Itraconazole and hydroxyl-itraconazole.
Concomitant use of Itraconazole and efavirenz is not recommended. In vivo studies have shown that nevirapine induces the metabolism of ketoconazole, significantly reducing the bioavailability of ketoconazole.
Studies involving nevirapine and Itraconazole have not been conducted. However, because of the similarities between ketoconazole and Itraconazole, concomitant administration of Itraconazole and nevirapine is not recommended.
Concomitant administration of Itraconazole and protease inhibitors metabolized by CYP3A4, such as indinavir, ritonavir, and saquinavir, may increase plasma concentrations of these protease inhibitors. In addition, concomitant administration of Itraconazole and indinavir and ritonavir but not saquinavir may increase plasma concentrations of Itraconazole.
Caution is advised when Itraconazole and protease inhibitors must be given concomitantly. Concomitant administration of Itraconazole and maraviroc has been reported to increase plasma concentration of maraviroc. The dose of maraviroc should be decreased to mg twice daily when given in combination with Itraconazole.
Antimycobacterials Drug interaction studies have demonstrated that plasma concentrations of azole antifungal agents and their metabolites, including Itraconazole and hydroxyitraconazole, were significantly decreased when these agents were given concomitantly with rifabutin or rifampin.
In vivo data suggest that rifabutin is metabolized in part by CYP3A4. Itraconazole may inhibit the metabolism of rifabutin. Although no formal study data are available for isoniazid, similar effects should be anticipated.
Therefore, the efficacy of Itraconazole could be substantially reduced if given concomitantly with one of these agents and co-administration is not recommended. Antineoplastics Itraconazole may inhibit the metabolism of busulfan, docetaxel, and vinca alkaloids.
Co-administration of pimozide with Itraconazole could result in serious cardiovascular events. Therefore, concomitant administration of Itraconazole and pimozide is contraindicated. Increases in plasma aripiprazole concentrations have been demonstrated in subjects concomitantly receiving ketoconazole, requiring a reduction of the aripiprazole dose.
Because of the similarities between ketoconazole and Itraconazole, a similar dose reduction for aripiprazole is recommended when patients concomitantly receive Itraconazole and aripiprazole.Yes, higher sales growth noted and most probably to continue. 11 Financial Accounting Workshop Pharmaniaga & Hovid • GPM of Hovid – likelihood to increase – .
Healthy orderbook of RMbil will provide earnings visibility for at least the next 2 years. Company is a good proxy to infra play in Msia MRT2, LRT3 n highway subcontract jobs other than RAPID that’s expected be awarded in the 2H. Jun 23, · With Pharmaniaga expanding its business overseas, the Biosis Group can take advantage of Pharmaniaga’s strengths to tap into its overseas markets.
For the 15 months ended March 31 , the company has group shareholders’ funds of rm million. Oct 17, · The six-month extension closely resembles a similar experience involving Pharmaniaga with regard to the renewal of its pharmaceutical distribution concession in late At that time, Pharmaniaga got a six-month extension, during which it was .
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